Thomas Partey, a key member of the Black Stars, suffered an injury shortly before the match against Brazil last Friday and will not participate against Nicaragua on Tuesday.
The RCD Mallorca midfielder Baba Iddrisu took over at halfback for the Arsenal player, who will now likely return to London for evaluation.
This is a major setback for Ghana as the Black Stars get ready for the FIFA World Cup in Qatar in 2022, since one of its key players is battling an injury.
After scoring the lone goal in Ghana’s victory over Nigeria, the man helped the country qualify for the World Cup.
In the final friendly matchup with Switzerland, scheduled for next month, Partey is anticipated to return.